Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia

DNA Methylation and the Expression of the Tumor-Suppressor Genes Protocadherin-10 and Reprimo in Pediatric Acute Lymphoblastic Leukemia

Background: Acute lymphoblastic leukemia (ALL) is the most prevalent hematologic malignancy among children. DNA methylation is well known to play a role in the initiation and progression of cancer. This research aimed to characterize the epigenetic inactivation and gene expression of Protocadherin-10 (PCDH10) and Reprimo (RPRM) in pediatric acute lymphoblastic leukemia, which is associated with...

Changes in Expression of miR-1297 and PTEN Tumor Suppressor Gene in T-cell Acute Lymphoblastic Leukemia

Background and purpose: T-cell acute lymphoblastic leukemia (T-ALL) is a type of blood malignancy caused by changes in the precursors of T lymphocyte cells. The PTEN gene is one of the most common tumor suppressor genes that mutates in most human cancers, including T-ALL. Therefore, it is important to identify miRNAs that target the PTEN gene in T-ALL. For this purpose, in the present study, mi...

p15INK4b, a Tumor Suppressor in Acute Myeloid Leukemia

Aberrant EPHB4 gene methylation and childhood acute lymphoblastic leukemia

The present study aimed to investigate the association between aberrant DNA methylation of the promoter region of the ephrin type-B receptor 4 (EPHB4) gene and the development of childhood acute lymphoblastic leukemia (ALL). Bisulfite sequencing polymerase chain reaction (BSP) was performed to determine the methylation density of cytosine-guanine pair islands in the promoter region of EPHB4, in...

Assocition between LAPTM4B gene polymorphism and the risk of childhood acute lymphoblastic leukemia

Introduction: Evidence suggests that Lysosome associated protein transmembrane 4B (LAPTM4B) contributes to the risk of numerous cancers. The present study aimed to find out the impact of LAPTM4B polymorphism on the risk of childhood acute lymphoblastic leukemia (ALL) in the southeastern Iranian population. Materials and Methods: A total of 230 subjects including 110 children diagnosed with ALL ...